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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 592082Generated: October 30, 2026

4-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde → 4-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehyde

https://huagongshe.com/reaction/592082

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehydeHCID 39162177—
Reactant3-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehydeHCID 89725870—
Product4-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehydeHCID 8972600566%

Reaction Steps

4-(2-oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde (55) was treated in an analogous manner to compound 51 to yield the desired product (66%) as a colorless oil. LCMS: 96% (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09238656B2
Source datasetuspto-grants-2016_01
ORD IDord-5f4e6e61737e4d9ea108f611bc7b0e09
Source noteuspto-grants-2016_01