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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 592088Generated: November 1, 2026

Trifluoroacetic acid → HCID 89726233, compound

https://huagongshe.com/reaction/592088

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactanttert-Butyl 4-(3-formylphenoxy)piperidine-1-carboxylateHCID 53439173—
SolventDichloromethaneHCID 6344—
ProductHCID 89726233HCID 89726233—

Reaction Steps

tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate (61) (5.55 mmol) was taken in DCM and cooled to 0° C. when TFA (5 ml) was added drop wise and then stirred at rt for 16 h when TLC confirmed completion of reaction. The reaction mixture was concentrated and used directly for the next step. White solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09238656B2
Source datasetuspto-grants-2016_01
ORD IDord-3a4fccb6708048f1a3076f438139c3ae
Source noteuspto-grants-2016_01