Trifluoroacetic acid → HCID 89726233, compound

HRID 592088Notes

Reaction equation

HRID 592088 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[O:6][CH:7]1[CH2:12][CH2:11][N:10]([C:13](OC(C)(C)C)=[O:14])[CH2:9][CH2:8]1)=[O:2].C(O)([C:25]([F:28])([F:27])[F:26])=O>C(Cl)Cl>[F:26][C:25]([F:28])([F:27])[C:13]([N:10]1[CH2:11][CH2:12][CH:7]([O:6][C:5]2[CH:4]=[C:3]([CH:22]=[CH:21][CH:20]=2)[CH:1]=[O:2])[CH2:8][CH2:9]1)=[O:14]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53439173tert-Butyl 4-(3-formylphenoxy)piperidine-1-carboxylate

Product 1

HCID 89726233HCID 89726233, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate (61) (5.55 mmol) was taken in DCM and cooled to 0° C. when TFA (5 ml) was added drop wise and then stirred at rt for 16 h when TLC confirmed completion of reaction. The reaction mixture was concentrated and used directly for the next step. White solid.

Workup

  1. additionwas added drop wise
  2. customcompletion of reaction
  3. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-3a4fccb6708048f1a3076f438139c3ae
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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