huagongshe.com
HRID592090

反应详情

EQUATION

反应方程式

HRID 592090 的结构方程式

REACTANTS

反应物

2
结构：O=Cc1cccc(OCC(=O)O)c1
HCID601895

3-Formylphenoxyacetic acid

C9H8O4

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4cccc(OCC(=O)O)c4)nc23)[C@H]2C=C[C@@H]1C2
HCID178513996

未命名化合物

收率 31%

PROCEDURE

实验过程

(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (1 eq.) and 2-(3-Formylphenoxy)acetic acid (48) (1.1 eq) were reacted in an analogous manner as compound CCXXIII to yield the desired product (31%) as a brown solid. NMR: δ (1H, 400 MHz, DMSO-d6): 1.38 (1H, d, J=8.8 Hz), 2.23 (1H, d, J=8.4 Hz), 2.63 (1H, d, J=8 Hz), 2.78-2.88 (2H, m), 4.26 (2H, s), 5.20 (1H, t, J=8.4 Hz), 6.36-6.42 (2H, m), 6.90 (1H, d, J=8.8 Hz), 7.14 (1H, d, J=8.8 Hz), 7.21 (1H, bs), 7.36 (1H, t, J=7.2 Hz), 7.60-7.70 (2H, m), 7.78 (1H, s), 7.94 (1H, s).