2-(3-Formylphenoxy)acetic acid → HCID 178513996, compound

Participants

Reaction Steps

(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (1 eq.) and 2-(3-Formylphenoxy)acetic acid (48) (1.1 eq) were reacted in an analogous manner as compound CCXXIII to yield the desired product (31%) as a brown solid. NMR: δ (1H, 400 MHz, DMSO-d6): 1.38 (1H, d, J=8.8 Hz), 2.23 (1H, d, J=8.4 Hz), 2.63 (1H, d, J=8 Hz), 2.78-2.88 (2H, m), 4.26 (2H, s), 5.20 (1H, t, J=8.4 Hz), 6.36-6.42 (2H, m), 6.90 (1H, d, J=8.8 Hz), 7.14 (1H, d, J=8.8 Hz), 7.21 (1H, bs), 7.36 (1H, t, J=7.2 Hz), 7.60-7.70 (2H, m), 7.78 (1H, s), 7.94 (1H, s).

Provenance & Evidence