Hydrazine hydrate (1:1) → HCID 66690636, compound

HRID 592293Notes

Reaction equation

HRID 592293 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:14]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].O.[NH2:17][NH2:18]>C(O)C>[Cl:1][C:2]1[C:3]([NH:17][NH2:18])=[N:4][CH:5]=[C:6]([CH:14]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10933837HCID 10933837, compound

Product 1

HCID 66690636HCID 66690636, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

To a solution of tert-butyl 5,6-dichloronicotinate (2.0 g, 8.1 mmol)) in ethanol (40.3 mL) was added hydrazine hydrate (1.18 mL, 24.2 mmol). The mixture was heated 75° C. After 18 h, the mixture was cooled to ambient temperature. The mixture was concentrated to dryness: LC-MS [M+1]=244.1.

Workup

  1. temperaturethe mixture was cooled to ambient temperature
  2. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-21237ceca1e849fc939313b08bfa33d0
Source dataset
uspto-grants-2016_01
Patent number
US09238647B2

Reaction notes

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