HCID 66690551, compound → HCID 66690544, compound

HRID 592307Notes

Reaction equation

HRID 592307 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([OH:14])=[C:12]([N+:15]([O-])=O)[CH:11]=[C:10]([C:18]([O:20][CH3:21])=[O:19])[CH:9]=2)=[CH:4][CH:3]=1>C(O)C.[Pd]>[NH2:15][C:12]1[CH:11]=[C:10]([C:18]([O:20][CH3:21])=[O:19])[CH:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:13]=1[OH:14]

Participants

4

Reactant 1

HCID 66690551HCID 66690551, compound

Product 1

HCID 66690544HCID 66690544, compoundYield 85.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The solution of methyl 4′-fluoro-6-hydroxy-5-nitrobiphenyl-3-carboxylate (13.0 mg, 45.0 μmol) and palladium (10% on carbon; 4.75 mg, 4.46 μmol) in ethanol (5 mL) was degassed and stirred under hydrogen at 1 atm. After 1 h, the mixture was filtered and washed with ethanol. The filtrate was concentrated to dryness to give the title compound (10 mg). LC-MS [M+1]=262.1.

Workup

  1. filtrationthe mixture was filtered
  2. washwashed with ethanol
  3. concentrationThe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-7847f196220f457fb7367521dc57dfdf
Source dataset
uspto-grants-2016_01
Patent number
US09238647B2

Reaction notes

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