反应详情

温度

25 °C

To a mixture of 117a (260 mg, 0.5 mmol) in acetic acid (15 mL) was added H2O2 (aq. 30%) (7.5 mL) and the reaction mixture was stirred overnight at 25° C. The reaction solution was poured into water and extracted with EtOAC and concentrated to a pale yellow liquid, purified by silica gel with (EtOAC/PE:1:3) to give 117b (2 g, 86%). MS: [M+H]+ 203.

1. extractionextracted with EtOAC
2. concentrationconcentrated to a pale yellow liquid
3. custompurified by silica gel with (EtOAC/PE:1:3)