tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate → HCID 86684213, compound

HRID 592603Notes

Reaction equation

HRID 592603 reaction equation
NC1N=CC(N2CCN(C(OC(C)(C)C)=O)CC2)=CC=1.[CH3:21][C@@H:22]1[CH2:27][N:26]([C:28]2[CH:29]=[N:30][C:31]([N+:34]([O-])=O)=[CH:32][CH:33]=2)[C@@H:25]([CH3:37])[CH2:24][N:23]1[C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39]>>[NH2:34][C:31]1[N:30]=[CH:29][C:28]([N:26]2[C@@H:25]([CH3:37])[CH2:24][N:23]([C:38]([O:40][C:41]([CH3:42])([CH3:44])[CH3:43])=[O:39])[C@H:22]([CH3:21])[CH2:27]2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 11737525tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylateHCID 86683703HCID 86683703, compound

Product 1

HCID 86684213HCID 86684213, compoundYield 83%

Procedure

Following the procedures as described for compound 101h, reaction of 122a (1.5 g, 4.46 mmol) afforded 122b as a yellow solid (1130 mg, 83%). LCMS: [M+H]+ 307

Sources & evidence

ORD record
ord-a8da63cf43d74f31a95623063232f128
Source dataset
uspto-grants-2016_01
Patent number
US09238655B2

Reaction notes

Loading…