HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate → (2R,5S)-tert-Butyl 4-(6-Aminopyridin-3-yl)-2,5-dimethylpiperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | HCID 11737525 | — |
| Reactant | HCID 86683703 | HCID 86683703 | — |
| Product | (2R,5S)-tert-Butyl 4-(6-Aminopyridin-3-yl)-2,5-dimethylpiperazine-1-carboxylate | HCID 86684213 | 83% |
Reaction Steps
Following the procedures as described for compound 101h, reaction of 122a (1.5 g, 4.46 mmol) afforded 122b as a yellow solid (1130 mg, 83%). LCMS: [M+H]+ 307
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238655B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-a8da63cf43d74f31a95623063232f128 |
| Source note | uspto-grants-2016_01 |