反应详情

温度

125 °C

A mixture of 206a (2.24 g, 7.9 mmol), 6-nitropyridin-3-ol (1.0 g, 7.2 mmol), and Cs2CO3 (2.6 g, 7.9 mmol) in DMF (8 mL) was heated at 125° C. in a sealed tube overnight. The solid was filtered and washed with ethyl acetate (2×20 mL). The combined filtrate was evaporated in vacuo and the residue was purified on reverse-phase Combiflash to afford 206b (1.25 g, 59%). MS-ESI: [M+H]+ 296.

1. filtrationThe solid was filtered
2. washwashed with ethyl acetate (2×20 mL)
3. customThe combined filtrate was evaporated in vacuo
4. customthe residue was purified on reverse-phase Combiflash