反应详情

A 100-mL round-bottomed flask equipped with a reflux condenser was charged with 206c (950 mg, 3.6 mmol), XantPhos (125 mg, 0.29 mmol), Pd2dba3 (260 mg, 0.29 mmol), 3,5-dibromo-1-methylpyridin-2(1H)-one (1.03 g, 3.9 mmol), Cs2CO3 (1.8 g, 7.2 mmol), and 1,4-dioxane (20 mL). The system was evacuated and refilled with N2. It was then heated at reflux for 2 h. After the completion of the reaction, the mixture was filtered off and washed with methanol (100 mL). The combined filtrate was evaporated in vacuo and the residue was purified on reverse-phase Combiflash to afford 206d (1.46 g, 90%). MS-ESI: [M+H]+ 451.

1. customA 100-mL round-bottomed flask equipped with a reflux condenser
2. customThe system was evacuated
3. additionrefilled with N2
4. temperatureIt was then heated
5. temperatureat reflux for 2 h
6. customAfter the completion of the reaction
7. filtrationthe mixture was filtered off
8. washwashed with methanol (100 mL)
9. customThe combined filtrate was evaporated in vacuo
10. customthe residue was purified on reverse-phase Combiflash