Trifluoroacetic acid → 2-(2,5-Dimethyl-1H-pyrrol-1-yl)-4-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine

HRID 593066Notes

Reaction equation

HRID 593066 reaction equation
[C:1]([C:4]1[N:8]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[N:7]=[C:6]([N:19]2[C:23]([CH3:24])=[CH:22][CH:21]=[C:20]2[CH3:25])[CH:5]=1)(=O)[CH3:2].C(O)(C(F)(F)F)=O>ClCCl>[CH3:25][C:20]1[N:19]([C:6]2[CH:5]=[C:4]3[C:1]([CH3:2])=[N:11][CH2:10][CH2:9][N:8]3[N:7]=2)[C:23]([CH3:24])=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86684524tert-Butyl 2-(5-Acetyl-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-1-yl)ethylcarbamate

Product 1

HCID 866845252-(2,5-Dimethyl-1H-pyrrol-1-yl)-4-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 287e(5.40 g, 1.0 eq., 15.6 mmol), CF3COOH (10 mL), and dichloromethane (50 mL). The mixture was stirred at room temperature for 1 h and concentrated under reduced pressure to afford crude 287f, which was used in the next step without further purification. MS-ESI: [M+H]+ 229.1

Workup

  1. customA 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ce8560041537439c83129ac16ff1ffc4
Source dataset
uspto-grants-2016_01
Patent number
US09238655B2

Reaction notes

Loading…