反应详情

A 25-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 318a (200 mg, 1.0 eq., 0.32 mmol), lithium hydroxide (38 mg, 5.0 eq., 1.60 mmol), i-propanol/THF (8/8 mL), and water (2 mL). The mixture was stirred at room temperature for 1 h and concentrated under reduced pressure. The residue was added partitioned between water and dichloromethane. The combined organic layer was concentrated under reduced pressure. The residue was purified by reverse-phase prep-HPLC to afford racemic mixture 318b as a yellow solid (91 mg, 43%).

1. customA 25-mL single-neck round-bottomed flask equipped with a magnetic stirrer
2. concentrationconcentrated under reduced pressure
3. additionThe residue was added
4. custompartitioned between water and dichloromethane
5. concentrationThe combined organic layer was concentrated under reduced pressure
6. customThe residue was purified by reverse-phase prep-HPLC