3-Aminopropionitrile → HCID 86684614, compound

HRID 593187Notes

Reaction equation

HRID 593187 reaction equation
CO[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]2[N:11]=[C:12]([N+:14]([O-:16])=[O:15])[CH:13]=[C:7]2[CH2:6]1.[NH2:17][CH2:18]CC#N>>[N+:14]([C:12]1[CH:13]=[C:7]2[CH2:6][N:5]([CH2:4][CH2:3][C:18]#[N:17])[CH2:10][CH2:9][N:8]2[N:11]=1)([O-:16])=[O:15]

Participants

3

Reactant 2

HCID 16473-AminopropionitrileHCID 866839905-(2-Methoxyethyl)-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

Product 1

HCID 86684614HCID 86684614, compoundYield 81.4%

Procedure

Following the procedure of Example 296d, and starting with 1-(2-bromoethyl)-5-(chloromethyl)-3-nitro-1H-pyrazole 296d (268 mg, 1.00 mmol) and 3-aminopropanenitrile (210 mg, 3.00 mmol) afforded 338a as a white solid (180 mg, 81%). MS-ESI: [M+H]+ 222.1

Sources & evidence

ORD record
ord-77d3f6bcbbc74a4abe917c5747a8b471
Source dataset
uspto-grants-2016_01
Patent number
US09238655B2

Reaction notes

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