Bromine → HCID 67814920, compound

HRID 593200Notes

Reaction equation

HRID 593200 reaction equation
[Br:1]Br.[CH3:3][CH:4]([CH3:13])[C:5]([C:7]1[CH:8]=[N:9][CH:10]=[N:11][CH:12]=1)=[O:6]>Br>[Br:1][C:4]([CH3:13])([CH3:3])[C:5]([C:7]1[CH:12]=[N:11][CH:10]=[N:9][CH:8]=1)=[O:6]

Participants

4

Reactant 2

HCID 24408BromineHCID 13645651HCID 13645651, compound

Product 1

HCID 67814920HCID 67814920, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent2×

Procedure

At room temperature, 11.8 ml (229.8 mmol) of bromine, dissolved in 111.5 ml of hydrobromic acid, were added to 28.7 g (191.5 mmol) of 2-methyl-1-(pyrimidin-5-yl)propan-1-one dissolved in 463 ml of hydrobromic acid. After the addition had ended, the reaction mixture was stirred overnight. The reaction mixture was then concentrated under reduced pressure. This gave 50.8 g (91%) of the desired product, which was reacted without further purification.

Workup

  1. additionAfter the addition
  2. concentrationThe reaction mixture was then concentrated under reduced pressure
  3. customThis gave 50.8 g (91%) of the desired product, which was reacted without further purification

Sources & evidence

ORD record
ord-0723e817914f4f4496bb64258035c903
Source dataset
uspto-grants-2016_01
Patent number
US09241487B2

Reaction notes

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