Sulfanilamide → HCID 68287865, compound

HRID 593280Notes

Reaction equation

HRID 593280 reaction equation
F[C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:12][CH:11]=1>O.C(#N)C>[I:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([NH2:19])(=[O:17])=[O:18])=[CH:12][CH:11]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 5333SulfanilamideHCID 70235702-Fluoro-4-iodopyridine

Product 1

HCID 68287865HCID 68287865, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Conditions

Temperature
150 °C

Procedure

A mixture of 2-fluoro-4-iodopyridine (1.0 g, 4.48 mmol) and 4-aminobenzenesulfonamide (772 mg, 4.48 mmol) was heated with an oil bath for 3 hours at 150° C. The title compound A4 was obtained from the residue by preparative HPLC (water/ACN gradient). Yield: 135 mg (8%). MS (ES) C11H10IN3O2S requires: 375. found: 376 (M+H)+.

Sources & evidence

ORD record
ord-a826135d60454f5ebeda7e3fbd3c336c
Source dataset
uspto-grants-2016_01
Patent number
US09242937B2

Reaction notes

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