4-(4-fluoro-2-methoxyphenyl)-N-(3-nitrophenyl)pyridin-2-amine → N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)benzene-1,3-diamine

Participants

Reaction Steps

To a solution of C2 (98 mg, 0.29 mmol) in THF/MeOH 1:1 (20 mL) was added Pd/C (10% w/w, 46 mg). The reaction mixture was stirred under hydrogen atmosphere (1 atm) at RT for 15 hours. The suspension was filtered through a pad of Celite® and the solvent was removed in vacuo to leave the desired product I1 as a brown solid (89 mg, 99%). MS (ES) C18H16FN3O requires: 309. found: 310 (M+H)+.

Provenance & Evidence