Thionyl Chloride → HCID 63428983, compound

HRID 593387Notes

Reaction equation

HRID 593387 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)O)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:19])=O>ClCCl>[Cl:19][CH:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([I:1])[CH:3]=1)[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 61101071HCID 61101071, compound

Product 1

HCID 63428983HCID 63428983, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (3-iodophenyl)-p-tolylmethanol (2.68 g) in dichloromethane (50 mL) at 0° C. is slowly added thionyl chloride (633 μL). After stirring at room temperature for 2 days, the mixture is washed with aqueous NaHCO3, dried over magnesium sulfate and concentrated under reduced pressure to afford chloro-(3-iodophenyl)-p-tolylmethane.

Workup

  1. customat 0° C.
  2. washthe mixture is washed with aqueous NaHCO3
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-bbe7909b5c4d4f4db7db871502c1cd92
Source dataset
uspto-grants-2016_01
Patent number
US09242959B2

Reaction notes

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