N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amine → (1E,4E)-2-amino-N-(2,3-dihydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

HRID 593436Notes

Reaction equation

HRID 593436 reaction equation
C(OC([NH:8][C:9]1[CH2:10][C:11]([C:33](O)=[O:34])=[CH:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[O:27])=[CH:22][CH:21]=3)=[CH:16][C:14]=2[N:15]=1)=O)(C)(C)C.CC1(C)[O:41][CH:40]([CH2:42][NH:43][CH2:44][CH2:45][CH3:46])[CH2:39][O:38]1>>[NH2:8][C:9]1[CH2:10][C:11]([C:33]([N:43]([CH2:42][CH:40]([OH:41])[CH2:39][OH:38])[CH2:44][CH2:45][CH3:46])=[O:34])=[CH:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][C:23]([C:26]([N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)=[O:27])=[CH:24][CH:25]=3)=[CH:16][C:14]=2[N:15]=1

Participants

3

Reactant 2

HCID 57577780N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amineHCID 66960164(1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid

Product 1

HCID 51033629(1E,4E)-2-amino-N-(2,3-dihydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Procedure

The title compound was prepared by the procedures as described in Example 101 (Step H and I) using (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid and N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amine.

Sources & evidence

ORD record
ord-f7e12991b1234ba2aeecb45cab921d0e
Source dataset
uspto-grants-2016_01
Patent number
US09242964B2

Reaction notes

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