HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amine → (1E,4E)-2-amino-N-(2,3-dihydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amine | HCID 57577780 | — |
| Reactant | (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid | HCID 66960164 | — |
| Product | (1E,4E)-2-amino-N-(2,3-dihydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide | HCID 51033629 | — |
Reaction Steps
The title compound was prepared by the procedures as described in Example 101 (Step H and I) using (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid and N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242964B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-f7e12991b1234ba2aeecb45cab921d0e |
| Source note | uspto-grants-2016_01 |