反应详情

温度

80 °C

The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customto give the crude material that
3. customwas purified by silica gel flash column chromatography