3-Bromopyridine → 6-chloro-2-pyridin-3-yl-1H-indole

HRID 593578Notes

Reaction equation

HRID 593578 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C([N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=2)[CH:17]=[C:16]1B(O)O)(OC(C)(C)C)=O>>[Cl:24][C:21]1[CH:22]=[C:23]2[C:18]([CH:17]=[C:16]([C:2]3[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=3)[NH:15]2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 441191511-Boc-6-chloroindole-2-boronic acid

Product 1

HCID 582156716-chloro-2-pyridin-3-yl-1H-indole

Procedure

3-Bromopyridine and N-Boc-6-chloro-indole-2-boronic acid are processed according to the procedure described in Example 91 to give 6-chloro-2-pyridin-3-yl-1H-indole. (ESI) m/z 229.0 (M+H)+.

Sources & evidence

ORD record
ord-73c7e5ec72564a0083f244411b8a72d3
Source dataset
uspto-grants-2016_01
Patent number
US09242963B2

Reaction notes

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