反应详情

5-(4-Chloro-5-phenylphthalazin-1-yl)pyridin-3-amine (0.800 g, 66.1% yield) was prepared from 1,4-dichloro-5-phenylphthalazine (1.00 g, 3.63 mmol), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (0.960 g, 4.36 mmol, commercial), K3PO4 (0.772 g, 3.63 mmol), Pd2(dba)3 (0.0330 g, 0.0360 mmol) and tricyclohexylphosphine (0.0200 g, 0.0730 mmol) by the methods described for the preparation of N-(tert-butyl)-5-(4-chloro-5-phenylphthalazin-1-yl)pyridine-3-sulfonamide in Example 1. The crude residue was taken to the next step without further purification. LCMS (Condition 11): retention time 0.86 min, [M+1]=333.1.

1. customThe crude residue was taken to the next step without further purification