HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid | HCID 90019421 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide | HCID 90018901 | — |
Reaction Steps
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-e69c6750c6694d3c9d9b32d018d9e3df |
| Source note | uspto-grants-2016_09 |