Ammonia → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide

HRID 59370Notes

Reaction equation

HRID 59370 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([O:17][CH3:18])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12](O)=[O:13])=[O:4].C(Cl)(=O)C(Cl)=O.[NH3:27]>C1COCC1>[F:1][C:2]([F:20])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([O:17][CH3:18])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([NH2:27])=[O:13])=[O:4]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 900194215-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid

Product 1

HCID 900189015-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-e69c6750c6694d3c9d9b32d018d9e3df
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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