HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide | HCID 90018901 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate | HCID 90019852 | — |
Reaction Steps
The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide (1.0 g, 3.6 mmol), oxalyl chloride (1.0 mL) and EDC (10 mL) to afford 0.750 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-42eae47f28024009a15b7de6a01799ba |
| Source note | uspto-grants-2016_09 |