Oxalyl chloride → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

HRID 59371Notes

Reaction equation

HRID 59371 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([O:17][CH3:18])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([NH2:14])=[O:13])=[O:4].C(Cl)(=O)[C:22](Cl)=[O:23]>C(Cl)CCl>[F:20][C:2]([F:1])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([O:17][CH3:18])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([N:14]=[C:22]=[O:23])=[O:13])=[O:4]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 900189015-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide

Product 1

HCID 900198525-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide (1.0 g, 3.6 mmol), oxalyl chloride (1.0 mL) and EDC (10 mL) to afford 0.750 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-42eae47f28024009a15b7de6a01799ba
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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