反应详情

A solution of (2-chloro-4-fluorophenyl)(3-fluoro-4-(pyrimidin-5-yl)pyridin-2-yl)methanone (0.030 g, 0.090 mmol) and hydroxylamine hydrochloride (0.043 g, 0.615 mmol) in pyridine (Volume: 0.452 ml) was refluxed for 3 hr, allowed to cool to room temperature, and then concentrated in vacuo. The crude material was dissolved in a minimal amount of CH2Cl2 to be chromatographed (required a few drops of MeOH). Purification of the crude material by silica gel chromatography using an ISCO machine (4 g column, 18 mL/min, 0-100% EtOAc in hexanes over 11 min, tr=0.4, 2 min) gave the title compound (29 mg, 0.079 mmol, 88% yield) as a yellow residue. ESI MS (M+H)+=347.0.

1. concentrationconcentrated in vacuo
2. dissolutionThe crude material was dissolved in a minimal amount of CH2Cl2
3. customto be chromatographed (required a few drops of MeOH)
4. customPurification of the crude material by silica gel chromatography
5. customan ISCO machine (4 g column, 18 mL/min, 0-100% EtOAc in hexanes over 11 min, tr=0.4, 2 min)