1-Bromo-2-methylpropane → HCID 89875838, compound

HRID 594123Notes

Reaction equation

HRID 594123 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:17]([O:18][CH3:19])=[CH:16][C:15]([CH:20]([CH3:22])[CH3:21])=[CH:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:23](N=C(N(C)C)N(C)C)([CH3:26])([CH3:25])[CH3:24].BrCC(C)C>C(#N)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]([CH2:24][CH:23]([CH3:26])[CH3:25])[C:12]2[C:17]([O:18][CH3:19])=[CH:16][C:15]([CH:20]([CH3:22])[CH3:21])=[CH:14][N:13]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 89875960HCID 89875960, compound

Product 1

HCID 89875838HCID 89875838, compoundYield 72.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound (46.8 mg) was prepared from 4-fluoro-N-(5-isopropyl-3-methoxypyridin-2-yl)benzenesulfonamide (55 mg, 0.170 mmol), 2-(tert-butyl)-1,1,3,3-tetramethylguanidine (0.068 mL, 0.339 mmol) in acetonitrile (4 mL) and 1-bromo-2-methylpropane (0.037 mL, 0.339 mmol) following the procedure described for Example 40. LCMS (2 min, formic) Rt 1.34 min, m/z (ES+) 381 (M+H).

Workup

  1. customLCMS (2 min, formic) Rt 1.34 min, m/z (ES+) 381 (M+H)

Sources & evidence

ORD record
ord-3216795e14cc4f5d8c4958856256f219
Source dataset
uspto-grants-2016_01
Patent number
US09242972B2

Reaction notes

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