3-Pyridazinamine, 6-ethoxy- → HCID 89876019, compound

HRID 594131Notes

Reaction equation

HRID 594131 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[N:8][C:7]([NH2:10])=[CH:6][CH:5]=1)[CH3:2].[CH3:11][C:12]1[C:16]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=2)=[C:15]([CH3:29])[O:14][N:13]=1>>[CH3:11][C:12]1[C:16]([CH2:17][O:18][C:19]2[CH:20]=[CH:21][C:22]([S:25]([NH:10][C:7]3[N:8]=[N:9][C:4]([O:3][CH2:1][CH3:2])=[CH:5][CH:6]=3)(=[O:27])=[O:26])=[CH:23][CH:24]=2)=[C:15]([CH3:29])[O:14][N:13]=1

Participants

3

Reactant 2

HCID 30847483-Pyridazinamine, 6-ethoxy-HCID 164907024-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chloride

Product 1

HCID 89876019HCID 89876019, compoundYield 4%

Procedure

The title compound (16 mg) was prepared from 6-ethoxypyridazin-3-amine (129 mg, 1.0 mmol) and 4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (0.302 g, 1.0 mmol), following the procedure described for Intermediate 51. LCMS (2 min, formic) Rt 0.91 min, m/z (ES+) 405 (M+H).

Workup

  1. customLCMS (2 min, formic) Rt 0.91 min, m/z (ES+) 405 (M+H)

Sources & evidence

ORD record
ord-726b1d7101dd43029f93e1a292dea8a8
Source dataset
uspto-grants-2016_01
Patent number
US09242972B2

Reaction notes

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