HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-Cyano-2-(difluoromethyl)nicotinoyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Cyano-2-(difluoromethyl)nicotinamide | HCID 90019373 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Cyano-2-(difluoromethyl)nicotinoyl isocyanate | HCID 90019224 | 88.4% |
Reaction Steps
The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-cyano-2-(difluoromethyl)nicotinamide (1.0 g), oxalyl chloride (3.2 g, 25.3 mmol) and DCM (20 mL) to afford 1.0 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-de1f4587e50a4570903c7ce295461570 |
| Source note | uspto-grants-2016_09 |