Oxalyl chloride → 5-Cyano-2-(difluoromethyl)nicotinoyl isocyanate

HRID 59416Notes

Reaction equation

HRID 59416 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]([F:14])[F:13])=[C:7]([CH:11]=1)[C:8]([NH2:10])=[O:9])#[N:2].C(Cl)(=O)[C:16](Cl)=[O:17]>C(Cl)Cl>[C:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]([F:14])[F:13])=[C:7]([CH:11]=1)[C:8]([N:10]=[C:16]=[O:17])=[O:9])#[N:2]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 900193735-Cyano-2-(difluoromethyl)nicotinamide

Product 1

HCID 900192245-Cyano-2-(difluoromethyl)nicotinoyl isocyanateYield 88.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-cyano-2-(difluoromethyl)nicotinamide (1.0 g), oxalyl chloride (3.2 g, 25.3 mmol) and DCM (20 mL) to afford 1.0 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-de1f4587e50a4570903c7ce295461570
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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