反应详情

温度

40 °C

A catalytic amount of tetrakistriphenylphosphinepalladium (0) (11.2 mg) was added to a mixture of the mono triflate 17 (380 mg), the pinnacol ester of 2-aminophenylboronic acid (124 mg) and sodium carbonate (120 mg) in ethanol (5 mL), toluene (5 mL) and water (5 mL). The reaction mixture was allowed to stir over night at room temperature and at 40° C. until the reaction was complete (c. 2 hr). The reaction mixture was diluted with ethyl acetate and the organic layer was washed with water and brine. The ethyl acetate solution was dried over magnesium sulphate and filtered under vacuum. Removal of ethyl acetate by rotary evaporation under reduced pressure afforded the crude product which was subjected to flash chromatography (silica gel, ethyl acetate/hexane). Pure fractions were collected and combined. Removal of excess eluent by rotary evaporation under reduced pressure afforded the pure product 103 (330 mg, 86% yield). LC/MS RT: 4.17 min, ES+1018.48.

1. custom(c. 2 hr)
2. washthe organic layer was washed with water and brine
3. dry with materialThe ethyl acetate solution was dried over magnesium sulphate
4. filtrationfiltered under vacuum
5. customRemoval of ethyl acetate
6. customby rotary evaporation under reduced pressure
7. customafforded the crude product which
8. customPure fractions were collected
9. customRemoval of excess eluent
10. customby rotary evaporation under reduced pressure