反应详情

A solution of (2-chloro-5-(pyridin-2-yl)phenyl)methanol (129 mg; 0.72 mmol) in anh. THF (7 ml) was treated with MnO2 (975 mg; 11.22 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 6.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with THF. The filtrate was concentrated to dryness under reduced pressure giving 2-chloro-5-(pyridin-2-yl)benzaldehyde as a yellow oil. LC-MS (conditions A): tR=0.43 min.; no ionisation.

1. customThe resulting reaction mixture
2. filtrationwas then filtered over celite
3. washthe separated solids were washed with THF
4. concentrationThe filtrate was concentrated to dryness under reduced pressure