反应详情

A solution of (6-(1H-pyrazol-1-yl)pyridin-2-yl)methanol (295 mg; 1.68 mmol) in anh. DCE (6 ml) was treated with MnO2 (1.174 g; 13.51 mmol), and the resulting mixture was stirred at reflux, under nitrogen, for 2 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 6-(1H-pyrazol-1-yl)picolinaldehyde as an off-white solid. LC-MS (conditions C): tR=0.74 min.; [M+H]+: 173.88 g/mol.

1. temperatureat reflux, under nitrogen, for 2 h
2. customthe resulting reaction mixture
3. filtrationwas filtered over celite
4. washthe separated solids were washed with DCM
5. concentrationThe filtrate was concentrated to dryness under reduced pressure