反应详情

A solution of 1-(4-(trifluoromethoxy)phenyl)propan-1-ol (300 mg; 1.36 mmol) in anh. DCM (10 ml) was treated at rt with CBr4 (451 mg; 1.36 mmol), and with PPh3 (357 mg; 1.36 mmol). The resulting mixture was further stirred at rt, under nitrogen, for 17 h. Concentration to dryness under reduced pressure, and subsequent purification by FC (DCM) afforded 1-(1-bromopropyl)-4-(trifluoromethoxy)benzene as a slightly yellow oil which was directly used for the next reaction. LC-MS (conditions A): tR=1.01 min.; no ionisation.

1. concentrationConcentration to dryness
2. customunder reduced pressure, and subsequent purification by FC (DCM)