HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(2,6-Dimethoxyphenyl)piperidin-2-one → 5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(2,6-Dimethoxyphenyl)piperidin-2-one | HCID 69082526 | — |
| Reactant | Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate | HCID 69085588 | — |
| Product | 5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one | HCID 69080143 | — |
Reaction Steps
5-(2,6-Dimethoxyphenyl)-3-methylpyrrolidin-2-one was prepared from ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate according to the procedure described for 6-(2,6-dimethoxyphenyl)piperidin-2-one. Subsequent purification by FC (DCM/MeOH=20/1) afforded 5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one as a light orange solid. LC-MS (conditions D): tR=0.84 min.; [M+H]+: 236.43 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-bd11ac94199e490a9bb7bc985002b7ec |
| Source note | uspto-grants-2016_01 |