反应详情

温度

0 °C

A cooled (0° C.) yellow solution of methyl 5-(2,4-dimethoxypyridin-3-yl)-5-(1,1-dimethylethylsulfinamido)pentanoate (653 mg; 1.75 mmol) in MeOH (14 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.90 ml; 3.60 mmol). The resulting yellow mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 1 h. The reaction mixture was then concentrated to dryness under reduced pressure and the yellow oily residue was further dried under HV to give the chlorhydrate salt of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate as a beige solid. LC-MS (conditions B): tR=0.51 min.; [M+H]+: 269.03 g/mol.

1. waitat rt for 1 h
2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
3. customthe yellow oily residue was further dried under HV