反应详情

温度

0 °C

A cooled (0° C.) slightly yellow solution of methyl 5-(4,6-dimethoxypyrimidin-5-yl)-5-(1,1-dimethylethylsulfinamido)pentanoate (178 mg; 0.47 mmol) in MeOH (4 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.24 ml; 0.96 mmol). The resulting yellow mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 5 h. The reaction mixture was then concentrated to dryness under reduced pressure and the yellow oily residue was further dried under HV to give methyl 5-amino-5-(4,6-dimethoxypyrimidin-5-yl)pentanoate HCl salt as a yellow solid. LC-MS (conditions A): tR=0.41 min.; [M+H]+: 270.10 g/mol.

1. waitat rt for 5 h
2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
3. customthe yellow oily residue was further dried under HV