反应详情

温度

0 °C

A cooled (0° C.) slightly yellow solution of ethyl 4-([1,1′-biphenyl]-2-yl)-4-(1,1-dimethylethylsulfinamido)-2-methylbutanoate (220 mg; 0.54 mmol) in MeOH (3 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.27 ml; 1.08 mmol). The resulting yellow mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 1 h. The reaction mixture was then concentrated to dryness under reduced pressure and the oily residue was further dried under HV to give the chlorhydrate salt of ethyl 4-([1,1′-biphenyl]-2-yl)-4-amino-2-methylbutanoate. LC-MS (conditions A): tR=0.63 min.; [M+H]+: 298.22 g/mol.

1. waitat rt for 1 h
2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
3. customthe oily residue was further dried under HV