反应详情

温度

0 °C

A cooled (0° C.) solution of methyl 5-(1,1-dimethylethylsulfinamido)-5-(2-methoxynaphthalen-1-yl)pentanoate (0.268 g; 0.68 mmol) in MeOH (5 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.35 ml; 1.40 mmol). The resulting mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 1 h. The reaction mixture was then concentrated to dryness under reduced pressure and the oily residue was further dried under HV to give the chlorhydrate salt of methyl 5-amino-5-(2-methoxynaphthalen-1-yl)pentanoate. LC-MS (conditions A): tR=0.55 min. and [M+H]+: 288.16 g/mol.

1. waitat rt for 1 h
2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
3. customthe oily residue was further dried under HV