4-Fluoro-3-(pyridin-2-yl)benzaldehyde → 6-(2,4-Dimethoxypyridin-3-yl)-1-(4-fluoro-3-(pyridin-2-yl)benzyl)piperidin-2-one

HRID 594477Notes

Reaction equation

HRID 594477 reaction equation
[NH2:1][CH:2]([C:10]1[C:11]([O:18][CH3:19])=[N:12][CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][C:22]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1>>[CH3:19][O:18][C:11]1[C:10]([CH:2]2[N:1]([CH2:25][C:24]3[CH:27]=[CH:28][C:21]([F:20])=[C:22]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH:23]=3)[C:6](=[O:8])[CH2:5][CH2:4][CH2:3]2)=[C:15]([O:16][CH3:17])[CH:14]=[CH:13][N:12]=1

Participants

3

Reactant 2

HCID 636811574-Fluoro-3-(pyridin-2-yl)benzaldehydeHCID 69082421Methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate

Product 1

HCID 690845956-(2,4-Dimethoxypyridin-3-yl)-1-(4-fluoro-3-(pyridin-2-yl)benzyl)piperidin-2-one

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate with 4-fluoro-3-(pyridin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.58 min.; [M+H]+: 421.83 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-51704af5fd274c3a964d4428916e64f0
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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