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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594477Generated: October 27, 2026

4-Fluoro-3-(pyridin-2-yl)benzaldehyde → 6-(2,4-Dimethoxypyridin-3-yl)-1-(4-fluoro-3-(pyridin-2-yl)benzyl)piperidin-2-one

https://huagongshe.com/reaction/594477

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-(pyridin-2-yl)benzaldehydeHCID 63681157—
ReactantMethyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoateHCID 69082421—
Product6-(2,4-Dimethoxypyridin-3-yl)-1-(4-fluoro-3-(pyridin-2-yl)benzyl)piperidin-2-oneHCID 69084595—

Reaction Steps

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate with 4-fluoro-3-(pyridin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.58 min.; [M+H]+: 421.83 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-51704af5fd274c3a964d4428916e64f0
Source noteuspto-grants-2016_01