HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene → 1-(3-Chloro-4-(trifluoromethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene | HCID 2773849 | — |
| Reactant | 6-(2,6-Dimethoxyphenyl)piperidin-2-one | HCID 69082526 | — |
| Product | 1-(3-Chloro-4-(trifluoromethoxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one | HCID 69083764 | — |
Reaction Steps
Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with commercially available 4-(bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.83 min.; [M+H]+: 444.11 g/mol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-76267b2bbca14a1c8087fabd605bd7b6 |
| Source note | uspto-grants-2016_01 |