Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594595Generated: October 30, 2026

6-(2,6-Dimethoxyphenyl)piperidin-2-one → 1-((6-(Difluoromethoxy)pyridin-3-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594595

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(2,6-Dimethoxyphenyl)piperidin-2-oneHCID 69082526—
Reactant5-(Bromomethyl)-2-(difluoromethoxy)pyridineHCID 69085387—
Product1-((6-(Difluoromethoxy)pyridin-3-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69082715—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 5-(bromomethyl)-2-(difluoromethoxy)pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.03 min.; [M+H]+: 393.53 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-8f92ce179b77464dac3d8303e5bdeb81
Source noteuspto-grants-2016_01