反应详情

A suspension of 5-fluoro-1-[[4-(1H-imidazol-1-yl)phenyl]methyl]-3-methyl-1H-indole-2-propanoic acid (1.0 g) in DMF (10 ml) is treated with SOCl2 (0.5 g) and, after cooling a gaseous NH3 is passed through the reaction mixture for 6 hours. The ammonium salt is filtered off and ether is added to the solution. The so obtained precipitated is filtered and dried to give 0.8 g of the title compound.

1. filtrationThe ammonium salt is filtered off
2. additionether is added to the solution
3. customThe so obtained
4. customprecipitated
5. filtrationis filtered
6. customdried