HCID 69081634, compound → HCID 69084623, compound

HRID 594603Notes

Reaction equation

HRID 594603 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1.Br[CH:19]([C:21]1[CH:22]=[C:23]([Cl:31])[C:24]([O:27][CH:28]([F:30])[F:29])=[N:25][CH:26]=1)[CH3:20]>>[Cl:31][C:23]1[CH:22]=[C:21]([CH:19]([N:16]2[CH:11]([C:4]3[C:5]([O:9][CH3:10])=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])[CH2:12][CH2:13][CH2:14][C:15]2=[O:17])[CH3:20])[CH:26]=[N:25][C:24]=1[O:27][CH:28]([F:30])[F:29]

Participants

3

Reactant 2

HCID 69081634HCID 69081634, compoundHCID 690825266-(2,6-Dimethoxyphenyl)piperidin-2-one

Product 1

HCID 69084623HCID 69084623, compound

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 5-(1-bromoethyl)-3-chloro-2-(difluoromethoxy)pyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.89 min., [M+H]+: 441.23 g/mol; tR=0.91 min., [M+H]+: 441.22 g/mol (diastereomers).

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-521f3ad661ff43ca86f085d203d2e7bd
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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