1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 5-(2-Ethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

HRID 594613Notes

Reaction equation

HRID 594613 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[NH:14][C:13](=[O:15])[CH2:12][CH2:11]1)[CH3:2].Br[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=1>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[N:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:26])([F:27])[F:28])=[CH:20][CH:19]=2)[C:13](=[O:15])[CH2:12][CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 690824815-(2-Ethoxyphenyl)pyrrolidin-2-one

Product 1

HCID 690836885-(2-Ethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

Procedure

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2-ethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.08 min.; [M+H]+: 379.99 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-4d5a9251f5c5415cb85d53f07a95eb86
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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