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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594613Generated: October 26, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 5-(2-Ethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594613

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
Reactant5-(2-Ethoxyphenyl)pyrrolidin-2-oneHCID 69082481—
Product5-(2-Ethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-oneHCID 69083688—

Reaction Steps

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2-ethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.08 min.; [M+H]+: 379.99 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-4d5a9251f5c5415cb85d53f07a95eb86
Source noteuspto-grants-2016_01